Лофацимиг

Prop. INN (наименование, предложенное ВОЗ)

2857858-76-3

only-heavy-chain immunoglobulin VH-VH-G1(h-CH2-CH3) dimer, anti-[Homo sapiens F11 (coagulation factor XI, FXI, plasma thromboplastin antecedent, PTA) apple 2 domain] and anti-[Homo sapiens F11 (coagulation factor XI, FXI, plasma thromboplastin antecedent, PTA) apple 3 domain] humanized monoclonal antibody, bispecific, tetravalent;
H-gamma1 heavy chain VH-VH-G1(h-CH2-CH3) (1-493) [VH anti-F11 apple 2 domain (Camelus dromedarius IGHV3S45*01 (86.6%)/Homo sapiens IGHV3-66*01 (83.5%) -(IGHD) -IGHJ5*02 (100%), CDR-IMGT [9.7.23] (26-34.52-58.97-119)) (1-130) -3-mer (glycyl-alanyl-prolyl) linker (131-133) -[VH anti-F11 apple 3 domain (Camelus dromedarius IGHV3S72*01 (81.2%)/Homo sapiens IGHV3-64*04 (79.4%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.20] (159-166.184-190.229-248)) (134-259) -2-mer (glycyl-seryl) linker (260-261) -Homo sapiens IGHG1*01 h-CH2-CH3-CHS G1m17,1 CH3 D12, L14, G1v37 h S5 (hinge 1-15 C5>S (266) (262-276), CH2 (277-386), CH3 D12 (402), L14 (404) (387-491), CHS (492-493)) (262-493)]; dimer (272-272':275-275')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

Поделиться этой страницей