Ломтеговимаб
LomtegovimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2550869-33-3
Химическое название
immunoglobulin G1-kappa, anti-[severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody;
gamma1 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV3- 33*03 (88.8%) -(IGHD) -IGHJ3*02 (90.9%) M123>L (115), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 (CH1 R120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS K>del (449)) (121- 449)], (223-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V- KAPPA (Homo sapiens IGKV1-5*03 (89.4%) -IGKJ4*01 (91.7%) E125>D (105), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229- 229'':232-232'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)- K1 cell line, glycoform alfa
gamma1 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV3- 33*03 (88.8%) -(IGHD) -IGHJ3*02 (90.9%) M123>L (115), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 (CH1 R120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS K>del (449)) (121- 449)], (223-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V- KAPPA (Homo sapiens IGKV1-5*03 (89.4%) -IGKJ4*01 (91.7%) E125>D (105), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229- 229'':232-232'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)- K1 cell line, glycoform alfa
Структура
Иностранные названия
- Lomtegovimabum (латинское)
- Lomtegovimab (английское)
- Lomtegovimab (немецкое)
- Lomtégovimab (французское)
- Lomtegovimab (испанское)
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