Ломвастомиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2648840-52-0

immunoglobulin G1-kappa with crossed domains, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)] and anti-[Homo sapiens HAVCR2 (hepatitis A virus cellular receptor 2, T cell immunoglobulin and mucin domains family member 3, TIM3, TIM-3, TIMD3, CD366)], humanized monoclonal antibody, bispecific;
gamma1 heavy chain with crossed V-kappa anti-PDCD1 (1-443) [V-KAPPA humanized (Homo sapiens IGKV4-1*01 (82.2%) -IGKJ1*01 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1-111) -2-mer biseryl linker (112-113) -Homo sapiens IGHG1*01, G1m17,1, G1v14-49 CH2 A1.3, A1.2, G114, G1v32 CH3 W22 (knob) (CH1 K120 (210) (114-211), hinge 1-15 (212-226), CH2 L1.3>A (230), L1.2>A (231), P114>G (325) (227- 336), CH3 D12 (352), L14 (354), S10>C (350), T22>W (362) (337- 441), CHS (442-443)) (112-443)], (216-227')-disulfide with kappa light chain with crossed VH anti-PDCD1 (1'-227') [VH humanized (Homo sapiens IGHV3-23*01 (90.6%) -(IGHD) -IGHJ5*01 (92.9%)), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1'-120') -Homo sapiens IGKC*01 (99.1%), R1.5>A (121), T1.4>S (122), Km3 A45.1 (166), V101 (204) (121'-227')]; gamma1 heavy chain anti-HAVCR2 (TIM3) (1''-449'') [VH humanized (Homo sapiens IGHV3-66*01 (74.5%) -(IGHD) -IGHJ6*01 T123>L (114) (90.9%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1''-119'') -Homo sapiens IGHG1*01, G1m17,1, G1v14-49 CH2 A1.3, A1.2, G114, G1v33 CH3 S22, A24, V86 (hole) (CH1 K26>E (149), K119>E (215), K120 (216) (120''-217''), hinge 1-15 (218''-232''), CH2 L1.3>A (236), L1.2>A (237), P114>G (331) (233''-342''), CH3 D12 (358), L14 (360) Y5>C (351),T22>S (368), L24>A (370), Y86>V (409)] (343''-447''), CHS (448''-449'')) (120''-449'')], (222''-214''')-disulfide with kappa light chain anti-HAVCR2 (TIM3) (1'''-214''') [Homo sapiens V-KAPPA (IGKV2-28*01 (81.0%) -IGKJ2*01 (91.7%)) [6.3.9], CDR-IMGT [6.3.9] (27-32.50-52.99-107) (1'''-107''') -Homo sapiens IGKC*01 (98.1%), E12>R (123), Q13>K (124) Km3 A45.1 (153), V101 (191) (108'''-214''')]; dimer (222-228":225-231":350-351")-trisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa

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