Лонигутамаб угодотин

Rec. INN (наименование, зарегистрированное ВОЗ)

2363754-30-5

immunoglobulin G1-kappa, anti-[Homo sapiens IGF1R (insulin like growth factor 1 receptor, IGF1-R, IGF-1R, CD221)], humanized monoclonal antibody conjugated to a dolastatin derivative (ugodotin groups);
gamma1 heavy chain humanized (1-449) [VH humanized (Homo sapiens IGHV1-46*01 (92.8%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1-120) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 (CH1 R120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS K>del (449)) (121-449)], (223-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA humanized (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ4*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO)-K1SV cell line lacking the glutamine synthetase gene (GSKO), glycoform alfa; conjugated at the cysteines 223, 214', 223'' and 214''' with four (3S,6R,7R,8²S,11R,12S,15S,18S,30³RS)-12-[(2S)-butan-2-yl]-3-carboxy-7,11-dimethoxy-6,13,19,23-tetramethyl-5,9,14,17,24,30²,30⁵-heptaoxo-15,18-di(propan-2-yl)-4,13,16,19,23-pentaaza-8(2,1),30(1)-dipyrrolidina-1(1),22(1,4)-dibenzenatriacontaphan-30³-yl (ugodotin) groups

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