Лонповамеран

Prop. INN (наименование, предложенное ВОЗ)

2972476-18-7

self-amplifying messenger RNA (mRNA), 5'-capped, encoding codon-optimised Venezuelan equine encephalitis virus (VEEV) RNA-dependent RNA polymerase (VEEV proteins nsP1, nsP2, nsP3 and nsP4) and a full-length codon-optimised pre-fusion stabilised conformation variant (K982P and V983P) of the SARS- CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein XBB.1.5 variant (derived from GenBank ID: UZG29433.1) containing furin cleavage-inactivating mutations (R678G, R679S and R681S), flanked by 5' and 3' untranslated regions and a 3' polyadenylation (polyA) tail; generation of capped S glycoprotein mRNA is under control of a VEEV subgenomic promoter

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