Лоригерлимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2416595-46-3

immunoglobulin G4 scFv-h-CH2-CH3_scFv, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)] and anti-[Homo sapiens CTLA4 (cytotoxic T- lymphocyte-associated protein 4, CD152)], chimeric, Homo sapiens and humanized monoclonal antibody, tetravalent, bispecific;
scFv-h-CH2-CH3, chimeric and Homo sapiens, anti-PDCD1 and anti-CTLA4 (1-499) [scFv-V-KAPPA-VH (1-237) [V- KAPPA anti-PDCD1 Musmus/Homsap (Mus musculus IGKV3-2*01 (80.8%) -(IGHD) -IGKJ2*01 (91.7%) L124>V(108)/Homo sapiens IGKV3D-11*02 (77.7%) -(IGHD) - IGKJ4*01 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1-111) -8 mer triglycyl-seryl-tetraglycyl linker (112- 119) -VH anti-CTLA4 (Homo sapiens IGHV3-30*01 (93.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.11] (145-152.170-177.216-226)) (120-237)] -E-coil linker (238-271) [6-mer diglycyl-cysteinyl-triglycyl linker (238-243) -28-mer (glutamyl-valyl-dialanyl-cysteinyl-glutamyl-lysyl)- tris(glutamyl-valyl-dialanyl-leucyl-glutamyl-lysyl) E-coil motif (244-271)] -[scFc Homo sapiens IGHG4*01 h-CH2-CH3, G4v5 h P10, G4v21 CH2 Y15.1, T16, E18 (hinge 1-12 S10>P (281) (272-283), CH2 M15.1>Y (305), S16>T (307), T18>E (309) (284-393), CH3 (394-498), CHS K2>del (499)) (272-499)] (248''-246')-disulfide with scFv-V-KAPPA-VH, Homo sapiens and humanized, anti-CTLA4 and anti- PDCD1(1'-269') [V-KAPPA anti-CTLA4 (Homo sapiens IGKV3-20*01 (99.0%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27-33.51-53.90-98)) (1'-108') -8 mer triglycyl-seryl- tetraglycyl linker (109'-116') -VH anti-PDCD1 (Homo sapiens IGHV1-46*01 (81.6%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.12] (142-149.167-174.213-224)) (117'-235')]-K-coil linker (236'-269') [6-mer diglycyl-cysteinyl-triglycyl linker (236'-241') -28-mer (lysyl-valyl-dialanyl-cysteinyl-lysyl- glutamyl)-tris(lysyl-valyl-dialanyl-leucyl-lysyl-glutamyl) K-coil motif (242'-269')]; dimer (279-279'':282-282'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-S cell line, glycoform alfa

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