Лосатуксизумаб
LosatuxizumabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB) delta 2-7 isoform (delta2-7EGFR, de2-7 EGFR, EGFRvIII)], humanized and chimeric monoclonal antibody;
humanized gamma1 heavy chain (1-446) [humanized VH (Homo sapiens IGHV4-30-4*01 (81.40%) -(IGHD) - IGHJ4*01) [9.7.9] (1-116) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (213) (117-214), hinge (215-229), CH2 (230-339), CH3 E12 (355), M14 (357) (340-444), CHS (445-446)) (117-446)], (219-214')- disulfide with chimeric kappa light chain (1'-214') [Mus musculus V-KAPPA (IGKV14-100*01 (86.30%) -IGKJ1*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (225-225'':228-228'')- bisdisulfide
humanized gamma1 heavy chain (1-446) [humanized VH (Homo sapiens IGHV4-30-4*01 (81.40%) -(IGHD) - IGHJ4*01) [9.7.9] (1-116) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (213) (117-214), hinge (215-229), CH2 (230-339), CH3 E12 (355), M14 (357) (340-444), CHS (445-446)) (117-446)], (219-214')- disulfide with chimeric kappa light chain (1'-214') [Mus musculus V-KAPPA (IGKV14-100*01 (86.30%) -IGKJ1*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (225-225'':228-228'')- bisdisulfide
Структура
Иностранные названия
- Losatuxizumabum (латинское)
- Losatuxizumab (английское)
- Losatuxizumab (немецкое)
- Losatuxizumab (французское)
- Losatuxizumab (испанское)
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