Лотивибарт

Prop. INN (наименование, предложенное ВОЗ)

2851892-98-1

immunoglobulin G1-kappa, anti-[HIV-1 (human immunodeficiency virus type 1) gp120 envelope glycoprotein, CD4-binding site], Homo sapiens monoclonal antibody;
H-gamma1 heavy chain Homo sapiens (1-452) [VH (Homo sapiens IGHV1-2*02 (59.2%) -(IGHD) -IGHJ1*01 (72.7%) L123>T (117), T125>V (119), S128>A (122), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v24 CH3 L107, S114 (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 D12 (361), L14 (363), M107>L (433), N114>S (439) (346-450), CHS (451-452)) (123-452)], (225-210')-disulfide with L-kappa light chain Homo sapiens (1'-210') [V-KAPPA (Homo sapiens IGKV1-13*02 (69.6%) -IGKJ5*01 (70.0%) Q120>R (96'), T122>S (98'), E1125>H (101'), CDR-IMGT [6.3.5] (27'-32'.50'-52'.89'-93')) (1'- 103') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C- KAPPA A45.1 (149'), V101 (187')) (104'-210')]; dimer (231- 231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa

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