Лукорафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2769742-99-4

humanized immunoglobulin G4-kappa, anti-[human TIGIT (T cell immunoreceptor with Ig domain and ITIM, V-set Ig member 9, VSIG9, V-set and transmembrane member 3, VSTM3)] fused at the C-terminus of the heavy chain, via a (G₄S)₄ peptide linker, to a fragment of the mature extracellular domain of human TGF-beta receptor type-2, glycoform alfa;
gamma 4 heavy chain (1-447) [VH (Homo sapiens IGHV4-30-4*01 - (IGHD) -IGHJ4*01, CDR-Kabat [6.16.12] (31-36.51-66.99-110)) (1-121) -Homo sapiens IGHG4*01 (CH1 (122-219), hinge S²²⁹>P (220-231), CH2 F²³⁵>A, L²³⁶>A (232-341), CH3 (342-446), CHS K⁴⁴⁸>del (447)) (122-447)] fused via a (G₄S)₄ peptide linker (448-467) to human TGF- beta receptor type-2 (TGFR-2, TGFBR2, transforming growth factor- beta receptor type II, TGFβ type II receptor, TGFβRII) extracellular domain fragment 23-159 (1-137 of the mature protein), [T²³>G⁴⁶⁸, S³¹>T⁴⁷⁶]-variant (468-604 in the current sequence), (135-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 -IGKJ1*01, CDR-Kabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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