Лунаксафусп

Rec. INN (наименование, зарегистрированное ВОЗ)

2642197-17-7

L-methionyl-Shiga-like toxin 1 subunit A1 (2-252), variant (S⁴⁵>I⁴⁶, V⁵⁴>I⁵⁵, R⁵⁵>L⁵⁶, I⁵⁷>F⁵⁸, P⁵⁹>F⁶⁰, E⁶⁰>T⁶¹, E⁶¹>L⁶², G¹¹⁰>A¹¹¹, R¹⁸⁸>A¹⁸⁹, C²⁴²>S²⁴³, R²⁴⁸>A²⁴⁹, R²⁵¹>A²⁵²), fused via the peptide linker ²⁵³EFPKPSTPPGSSGGAP²⁶⁸ to an anti-(human ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, CD340)) murine immunoglobulin single chain variable fragment (scFv) (269- 519), containing a VH region (269-387), a ³⁸⁸GGGGSGGGGSGGGGSGGGGSGGGGS⁴¹² peptide linker and a VL region (413-519), produced in Escherichia coli; methionyl (1)-Shiga-like toxin 1 subunit A1 (SLT-1 subunit A1, SLT-1a1, SLT-Ia1, sltA1, stxA1, verotoxin 1 subunit A1, verocytotoxin 1 subunit A1, rRNA N-glycosidase 1, EC:3.2.2.22) of enterobacteria phage H19B (bacteriophage H19B) (2-252), [S⁴⁵>I⁴⁶, V⁵⁴>I⁵⁵, R⁵⁵>L⁵⁶, I⁵⁷>F⁵⁸, P⁵⁹>F⁶⁰, E⁶⁰>T⁶¹, E⁶¹>L⁶², G¹¹⁰>A¹¹¹, R¹⁸⁸>A¹⁸⁹, C²⁴²>S²⁴³, R²⁴⁸>A²⁴⁹, R²⁵¹>A²⁵²]-mutant, fused via the 16-peptide linker EFPKPSTPPGSSGGAP (253-268, containing the murine IgG3 hinge fragment PKPSTPPGSS 255-264), to an anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)] single-chain Mus musculus immunoglobulin Fv fragment (269-387) [VH (Mus musculus IGHV9-1*02 (IGHD) -IGHJ2*01, CDR-Kabat [5.17.10] (299-303.318-334.367-376))], fused via a 25-peptide linker (G₄S)₅ (388-412), to an anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c- erbB2, NEU, CD340)] single-chain Mus musculus immunoglobulin Fv fragment (413-519), [VL (Mus musculus IGKV6-17*01 (IGHD) -IGKJ4*01, CDR-Kabat [11.7.9] (436-446.462-468.501-509))], non-glycosylated, produced in Escherichia coli

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