Лунсекимиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2770858-49-4

immunoglobulin single chain of 5 VH (sc-5-VH), anti-[Homo sapiens IL13 (interleukin 13, IL-13)], anti-[Homo sapiens TSLP (thymic stromal lymphopoietin)] and anti-[Homo sapiens ALB (albumin, human serum albumin, HAS)], monoclonal antibody sc-5-VH, humanized and chimeric, trispecific, pentavalent;
single chain of 5 VH (sc-5-VH) humanized and chimeric (1-671) [VH anti-IL13 chimeric Vicpac/Homsap (Vicugna pacos IGHV3-3*01 (87.6%) -(IGHD) -IGHJ2*01 (100%)/Homo sapiens IGHV3-23*04 (81.4%) -(IGHD) -IGHJ4*01 (85.7%), L50>R (45), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -35-mer hepta(tetraglycyl-seryl) linker (124-158) -VH anti-IL13 humanized (Homo sapiens IGHV3-43*02 (89.7%) -(IGHD) -IGHJ4*01 (92.9%) W118>R (274), CDR-IMGT [8.8.19] (184-191.209-216.255-273)) (159-284) -9-mer glycyl-bis(triglycyl-seryl) linker (285-293) -VH anti-TSLP chimeric Vicpac /Homsap (Vicugna pacos IGHV3S53*01 (76.8%) -(IGHD) -IGHJ2*01 (100%)/Homo sapiens IGHV3-66*01 (72.9%) -(IGHD) -IGHJ1*01 (100%), L50>R (338) (CDR-IMGT [8.7.11] (319-326.344-350.389-399)) (294-410) -9-mer glycyl-bis(triglycyl-seryl) linker (411-419) -VH anti-ALB humanized (Homo sapiens IGHV3-23*04 (88.5%) -(IGHD) -IGHJ1*01 (81.8%), L50>P (464), W118>S (524), CDR-IMGT [8.8.8] (445-452.470-477.516-523)) (420-534) -9-mer glycyl-bis(triglycyl-seryl) linker (535-543) -VH anti-TSLP chimeric Lamgla/Homsap (Lama glama IGHV3S1*01 (88.9%) -(IGHD) -IGHJ6*01 (85.7%)/Homo sapiens IGHV3-43*02 (82.8%) -(IGHD) -IGHJ5*02 (100%), L50>R (590), CDR-IMGT [10.8.18] (569-578.596-603.642-659)) (544-671)], produced in the yeast Pichia pastoris (Komagataella phaffii), non-glycosylated

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