Лупартумаб амадотин
Lupartumab amadotinМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
1640972-00-4
Химическое название
immunoglobulin G1-lambda1, anti-[Homo sapiens LYPD3 (Ly6/PLAUR domain containing 3, GPI-anchored cellsurface protein C4.4a, C4.4A)], Homo sapiens monoclonal antibody conjugated to an auristatin W derivative;
gamma1 heavy chain (1-446) [Homo sapiens VH (IGHV3- 48*03 (92.90%) -(IGHD) -IGHJ4*01) [8.8.10](1-117) - IGHG1*01, Gm17,1 (CH1 (118-215), hinge (216-230), CH2 (231-340), CH3 (341-445), CHS K>del (446)) (118-446)], (220-216')-disulfide with lambda1 light chain (1'-217') [Homo sapiens V-LAMBDA (IGLV1-47*01 (87.90%) - IGLJ2*01) [9.3.11] (1'-111') -IGLC2*01 (112'-217')]; dimer (226-226'':229-229'')-bisdisulfide; S-substituted on an average of 4 reduced cysteinyl by reaction with N-demethyl-N-[4-(6-maleimidohexanohydrazido)- 4-oxobutyl]auristatin W amide
gamma1 heavy chain (1-446) [Homo sapiens VH (IGHV3- 48*03 (92.90%) -(IGHD) -IGHJ4*01) [8.8.10](1-117) - IGHG1*01, Gm17,1 (CH1 (118-215), hinge (216-230), CH2 (231-340), CH3 (341-445), CHS K>del (446)) (118-446)], (220-216')-disulfide with lambda1 light chain (1'-217') [Homo sapiens V-LAMBDA (IGLV1-47*01 (87.90%) - IGLJ2*01) [9.3.11] (1'-111') -IGLC2*01 (112'-217')]; dimer (226-226'':229-229'')-bisdisulfide; S-substituted on an average of 4 reduced cysteinyl by reaction with N-demethyl-N-[4-(6-maleimidohexanohydrazido)- 4-oxobutyl]auristatin W amide
Структура
Иностранные названия
- Lupartumabum amadotinum (латинское)
- Lupartumab amadotin (английское)
- Lupartumab amadotin (немецкое)
- Lupartumab amadotine (французское)
- Lupartumab amadotina (испанское)
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