Лусвертикимаб
LusvertikimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2375835-91-7
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens IL7R (interleukin 7 receptor, CD127, IL7RA)], humanized monoclonal antibody;
gamma4 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-11*01 (90.8%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.15] (26-33.51-58.97-111) (1-122) -Homo sapiens IGHG4*01 (100%), G4v5 h P10 (CH1 (123-220), hinge 1-12 S10>P (230) (221-232), CH2 (233-342), CH3 (343-447), CHS (448-449)) (123-449)], (136-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (86.3%) -IGKJ4*01 (91.7%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 cell line, glycoform alfa
gamma4 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-11*01 (90.8%) -(IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.15] (26-33.51-58.97-111) (1-122) -Homo sapiens IGHG4*01 (100%), G4v5 h P10 (CH1 (123-220), hinge 1-12 S10>P (230) (221-232), CH2 (233-342), CH3 (343-447), CHS (448-449)) (123-449)], (136-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (86.3%) -IGKJ4*01 (91.7%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 cell line, glycoform alfa
Структура
Иностранные названия
- Lusvertikimabum (латинское)
- Lusvertikimab (английское)
- Lusvertikimab (немецкое)
- Lusvertikimab (французское)
- Lusvertikimab (испанское)
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