Лутаденовец аутоген

Prop. INN (наименование, предложенное ВОЗ)

2805319-15-5

replication-defective chimpanzee adenovirus 68 (ChAd68), subgroup E adenovirus, (C68, 68/SAdV-25, originally designated as Pan 9) vector, with E1, E3 and E4 (partially) deleted, encoding a patient- specific expression cassette comprising 20 tumour-specific neoantigens (TSNA). The expression cassette, introduced into the deleted viral E1 region, includes coding sequences for methionine, alanine and glycine (MAG), the 20 tumour-specific neoantigens, a class II helper domain consisting of two universal CD4+ T helper lymphocyte epitopes, the pan human leukocyte antigen (HLA) DR- binding epitope (PADRE) and the tetanus toxoid P2 epitope (amino acid 830-844 of tetanus toxin Tc), each linked by glycine and proline linkers (GPGPG). The expression cassette is under the control of a tetracycline repressor (tetR)-regulated cytomegalovirus (CMV) promoter and a simian virus 40 (SV40) polyadenylation signal

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