Лютеция (¹⁷⁷Lu) розопатамаб тетраксетан

Rec. INN (наименование, зарегистрированное ВОЗ)

2866236-96-4

immunoglobulin G1-kappa, anti-[Homo sapiens FOLH1 (folate hydrolase, prostate specific membrane antigen, PSMA)], lutetium (¹⁷⁷Lu) radiolabelled tetraxetan conjugate ;
H-gamma1 heavy chain (1-445) [VH Musmus/Homsap (Mus musculus IGHV1-26*01 (78.4%) -(IGHD) -IGHJ2*01 (92.9%) T123>L (110)/Homo sapiens IGHV1-69-2*01 (76.3%) -(IGHD) -IGHJ4*01 (92.9%) V124>L (111), CDR-IMGT [8.8.8] (26-33.51-58.97-104)) (1-115) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (212) (116-213), hinge 1-15 (214-228), CH2 (229-338), CH3 D12 (354), L14 (356) (339-443), CHS (444-445)) (116-445)], (218-214')-disulfide with L-kappa light chain (1'-214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV6-23*01 (81.8%) -IGKJ2*03 (72.7%) S120>P (100), L124>V (104), E125>D (105)/Homo sapiens IGKV1-13*02 (78.7%) -IGKJ3*01 (91.7%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')]; dimer (224-224'':227-227'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa; conjugated via the side chain nitrogen of an average of 4 lysine residues to lutetium (¹⁷⁷Lu) radiolabelled 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclodecan-1-yl]acetyl (tetraxetan, DOTA)

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