Лувелтамаб тазид

Rec. INN (наименование, зарегистрированное ВОЗ)

2493327-59-4

immunoglobulin G1-kappa, anti-[Homo sapiens FOLR1 (folate receptor 1, folate receptor alpha, FR-alpha, adult folate-binding protein, FBP, ovarian tumor-associated antigen MOv18)], humanized monoclonal antibody, genetically modified at four specific positions with reactive 4-(azidomethyl)-L-phenylalanine residues;
gamma1 heavy chain humanized (1-455) [VH (Homo sapiens IGHV3-66*01 (79.6%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.17] (27-34.52-59.98-114)) (1-125) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 Y85.2>F (pAMF) (188), R120>K (222) (126-223), hinge 1-15 (224-238), CH2 (239-348), CH3 E12 (364), M14 (366), F85.2>F (pAMF) (412) (349-453), CHS (454-455)) (126-455)], (228-215')-disulfide with kappa light chain humanized (1'-215') [V-KAPPA (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (28-33.51-53.90-98)) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')]; dimer (234-234'':237-237'')-bisdisulfide, produced by a cell-free protein synthesis system based on Escherichia coli lysate, non-glycosylated; conjugated at C-4 of the four l-phenylalanyl residues 188, 412, 188'' and 412'' with azidomethyl (tazide) groups

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