Мелредаблюкин альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2056881-92-4

human immunoglobulin G1 non-binding variant (heavy chain 1-444, L²³²>A, L²³³>A, P³²⁷>G) fused at the C-terminus of the heavy chain via peptidyl linker ⁴⁴⁵GGGGSGGGGSGGGGS⁴⁵⁹ to human interleukin 2 (1-133, 460-592 in the current sequence) variant (T³>A⁴⁶², N⁸⁸>D⁵⁴⁷, C125>A584), dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa;
human non-binding immunoglobulin G1 kappa (IgG1-κ) fused via a peptide linker to a mutated human interleukin 2 (IL2 mutein): fusion protein combining a gamma1 heavy chain (1-444) [Homo sapiens IGHV3-23*01; Homo sapiens IGHJ4*01; Homo sapiens IGHG1*01; VH: 1-115; CH1: 116-213; hinge: 214-228; CH2: 229-338 (L²³²>A, L²³³>A, P³²⁷>G); CH3: 339-443; CHS: 444-444 (K445del); CDR Kabat H1: SYAMS (31-35); CDR Kabat H2: AISGSGGSTYYADSVKG (50-66); CDR Kabat H3: GSGFDY (99- 104)], a (G4S)3 peptide linker (445-459), and Homo sapiens interleukin 2 (460-592) [T³>A⁴⁶², N⁸⁸>D⁵⁴⁷, C¹²⁵>A⁵⁸⁴]-variant, (218- 215')-disulfide with kappa light chain (1'-215') [Homo sapiens IGKV3-20*01; Homo sapiens IGKJ1*01; Homo sapiens IGKC*01; VL: 1-108; CL: 109-215; CDR Kabat L1: RASQSVSSSYLA (24-35); CDR Kabat L2: GASSRAT (51-57); CDR Kabat L3: QQYGSSPLT (90-98)]; dimer (224-224":227-227")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

Поделиться этой страницей