Мелрилимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB16373

2222865-46-3

immunoglobulin G2-kappa, anti-[Homo sapiens IL1RL1 (interleukin 1 receptor like 1, DER4, FIT-1, growth stimulation expressed 2 gene, ST2, IL33R)], Homo sapiens monoclonal antibody;
gamma2 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV3-23*01 (91.8%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.16] (26-33.51-58.97-112) (1-123) -Homo sapiens IGHG2*02v G2m23>G2m.., G2v3 CH2 A1.2, A1, S2, A30, L92, S115, S116 (CH1 T92 (195) (124-221), hinge 1-12 (222-233), CH2 V1.2>A (237), G1>A (239), P2>S (240), H30>A (270), M45.1>V (284), V92>L (311), A115>S (332), P116>S (333) (234-342), CH3 (343-447), CHS (448-449)) (124-449)], (137-214’)-disulfide with kappa light chain Homo sapiens (1’-214’) [V-KAPPA (Homo sapiens IGKV3D-11*02 (95.6%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1’-107’) -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108’-214’)]; dimer (225-225":226-226":229-229":232-232")-tetrakisdisulfide, produced in Chinese Hamster Ovary (CHO)-K1SV cell line lacking the Glutamine Synthetase (GS) gene, glycoform alfa

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