Миквотабарт пелидотин

Rec. INN (наименование, зарегистрированное ВОЗ)

2867550-00-1

immunoglobulin G1-kappa, anti-[Homo sapiens FN1 (fibronectin 1) extra domain B (ED-B) splice variant], Homo sapiens monoclonal antibody, conjugated through four cysteinyl residues to a derivative of auristatin;
H-gamma1 heavy chain Homo sapiens (1-445) [VH (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ4*01 (100%), CDR- IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v81 CH2 C81 (CH1 R120>K (213) (117-214), hinge 1-15 (215- 229), CH2 K81>C (230-339), CH3 E12 (355), M14 (357) (340- 444), CHS K2>del (445)) (117-445)], (219-215')-disulfide with L-kappa light chain Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV3-20*01 (94.8%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27'-33'.51'-53'.90'-98')) (1'-108') -Homo sapiens IGKC*01 (99.1%) Km3 A45.1 (154'), V101 (192'), KCv93 K93>C (184') (109'-215')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa; substituted at the sulfur atom of L-cysteinyl residues 289, 184', 289'' and 184''' with four (2S,5R,6R,7²S,10R,11S,14S,25S,28S,363RS)-2-benzyl-11-[(2S)- butan-2-yl]-25-[3-(carbamoylamino)propyl]-6,10-dimethoxy- 5,12,17,17-tetramethyl-4,8,13,16,19,24,27,30,362,365-decaoxo- 14,28-di(propan-2-yl)-20-oxa-3,12,15,18,23,26,29-heptaaza-1(2)- [1,3]thiazola-7(2,1),36(1)-dipyrrolidina-22(1,4)- benzenahexatriacontaphan-363-yl (pelidotin) groups

Поделиться этой страницей