Мипасетамаб
MipasetamabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens AXL (AXL receptor tyrosine kinase, tyrosine-protein kinase receptor UFO)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-451) [VH humanized (Homo sapiens IGHV3-30*03 (92.9%) -(IGHD) -IGHJ4*01 (92.3%)) CDR-IMGT [8.8.15] (26-33.51-58.97-111) (1-122) -Homo sapiens IGHG1*03, G1m3>G1m17, nG1m1 (CH1 R>K 120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 E12 (361), M14 (363) (346-450), CHS K>del (451)) (123-451)], (225-215')-disulfide with kappa light chain humanized (1'-215') [V-KAPPA humanized (Homo sapiens IGKV3-11*01 (84.4%) -IGKJ4*01 (90.9%)) CDR-IMGT [7.3.9] (27-33.51-53.90-98) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109’-215’)]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
gamma1 heavy chain humanized (1-451) [VH humanized (Homo sapiens IGHV3-30*03 (92.9%) -(IGHD) -IGHJ4*01 (92.3%)) CDR-IMGT [8.8.15] (26-33.51-58.97-111) (1-122) -Homo sapiens IGHG1*03, G1m3>G1m17, nG1m1 (CH1 R>K 120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 E12 (361), M14 (363) (346-450), CHS K>del (451)) (123-451)], (225-215')-disulfide with kappa light chain humanized (1'-215') [V-KAPPA humanized (Homo sapiens IGKV3-11*01 (84.4%) -IGKJ4*01 (90.9%)) CDR-IMGT [7.3.9] (27-33.51-53.90-98) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109’-215’)]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
Структура
Иностранные названия
- Mipasetamabum (латинское)
- Mipasetamab (английское)
- Mipasetamab (немецкое)
- Mipasétamab (французское)
- Mipasetamab (испанское)
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