Миплетамиг

Prop. INN (наименование, предложенное ВОЗ)

2839556-21-5

immunoglobulin IG chain scFvkh-G1hCH2CH3-scFvhk dimer bisdisulfide, anti-[Homo sapiens IL3RA (interleukin 3 receptor subunit alpha, interleukin 3 receptor alpha (low affinity), CD123)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], Homo sapiens and humanized monoclonal antibody, bispecific, tetravalent;
IG chain scFvkh-G1hCH2CH3-scFvhk Homo sapiens and humanized (1-757) [scFvkh anti-IL3RA Homo sapiens (1-259) [V-KAPPA (Homo sapiens IGKV4-1*01 (99.0%) -IGKJ4*01 (100%), CDR-IMGT [12.3.10] (27-38.56-58.95-104)) (1-114) -20-mer tetrakis(tetraglycyl-seryl) linker (115-134) -VH (Homo sapiens IGHV3-23*01 (98.0%) -(IGHD) -IGHJ3*02 (100%), CDR-IMGT [8.8.17] (160-167.185-192.231-247)) (135-259)] -Homo sapiens IGHG1*01, G1m17,1 CH3 D12, L14, G1v14-1 CH2 A1.3, A1.2, A1, G1v20 A105, G1v37 h S5 (hinge 1-15 C5>S (264) (260-274), CH2 L1.3>A (278), L1.2>A (279), G1>A (281), K105>A (366) (275-384), CH3 D12 (400), L14 (402) (385-489), CHS K2>del (490)) (260-490)] -18-mer (seryl-tris(glycyl-seryl)-prolyl-seryl) linker (491-508) -scFvhk anti-CD3E humanized (509-757) [VH (Homo sapiens IGHV1-69*02 (82.7%) -IGHD -IGHJ4*01 (92.9%), CDR-IMGT [8.8.14] (534-541.559-566.605-618)) (509-629) -20-mer tetrakis(tetraglycyl-seryl) linker (630-649) -V-KAPPA (Homo sapiens IGKV1-5*01 (81.5%) -IGKJ4*01 (100%), CDR-IMGT [5.3.9] (676-680.698-700.737-745)) (650-757)]]; dimer (270-270':273-273')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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