Миситатуг бливедотин

Rec. INN (наименование, зарегистрированное ВОЗ)

2767203-06-3

immunoglobulin G1-kappa, anti-[Homo sapiens MSLN (mesothelin, pre-pro-megakaryocyte-potentiating factor, megakaryocyte-potentiating factor, MPF, CAK1)]; conjugated on an average of 4 cysteinyl residues to monomethylauristatin E (MMAE), with a ratio of 1 to 2, via a cleavable divalent linker;
H-gamma1 heavy chain (1-454) [VH Musmus/Homsap (Mus musculus IGHV4-1*02 (91.8%) -(IGHD) -IGHJ1*01 (100%)/Homo sapiens IGHV3-74*03 (80.6%) Q120>A (116), M123>T (119) -(IGHD) -IGHJ3*01 (85.7%), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (221) (125-222), hinge 1-15 (223-237), CH2 (238-347), CH3 E12 (363), M14 (365) (348-452), CHS (453-454)) (125-454)], (227-213')-disulfide with L-kappa light chain (1'-213') [V-KAPPA Musmus/Homsap (Mus musculus IGKV4-55*01 (84.0%) -IGKJ1*01 (90.9%) L124>V (103)/Homo sapiens IGKV6-21*02 (68.4%) -IGKJ4*01 (100%), CDR-IMGT [5.3.9] (27'-31'.49'-51'.88'-96')) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152'), V101 (190') (107'-213')]; dimer (233-233'':236-236'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; substituted at the sulfur atoms of four l-cysteinyl residues on an average among 227, 233, 236, 213', 227'', 233'', 236'' and 213''' with two divalent radical groups consisting of 3,3'-[(2S,3R,6R,7R,8²S,11R,12S,15S,18S,26S,29S)-12-[(2S)-butan-2-yl]-26-[3-(carbamoylamino)propyl]-2-hydroxy-7,11-dimethoxy-3,6,13,19-tetramethyl-5,9,14,17,20,25,28,31,36-nonaoxo-15,18,29-tri(propan-2-yl)-21-oxa-33-thia-4,13,16,19,24,27,30-heptaaza-37(1)-[1,3,5]triazinana-8(2,1)-pyrrolidina-1(1),23(1,4)-dibenzenaheptatriacontaphane-37³,37⁵-diyl]bis(3-oxopropyl) (blivedotin)

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