Мупадолимаб
MupadolimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2451856-97-4
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens NT5E (5'-nucleotidase ecto, 5' nucleotidase, 5'-NT, NT5, CD73)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-452) [VH (Homo sapiens IGHV1-69*06 (82.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*01, G1m17,1, G1v36 CH2 N84.4>Q (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 N84.4>Q (302) (236-345), CH3 D12 (361), L14 (363) (346-450), CHS (451-452)) (123-452)], (225-218')-disulfide with kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV3D-11*02 (76.6%) -IGKJ1*01 (91.7%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO)-K1SV cell line lacking the glutamine synthetase gene (GS-KO), glycoform alfa
gamma1 heavy chain humanized (1-452) [VH (Homo sapiens IGHV1-69*06 (82.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*01, G1m17,1, G1v36 CH2 N84.4>Q (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 N84.4>Q (302) (236-345), CH3 D12 (361), L14 (363) (346-450), CHS (451-452)) (123-452)], (225-218')-disulfide with kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV3D-11*02 (76.6%) -IGKJ1*01 (91.7%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO)-K1SV cell line lacking the glutamine synthetase gene (GS-KO), glycoform alfa
Структура
Иностранные названия
- Mupadolimabum (латинское)
- Mupadolimab (английское)
- Mupadolimab (немецкое)
- Mupadolimab (французское)
- Mupadolimab (испанское)
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