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Rec. INN (наименование, зарегистрированное ВОЗ)

2750031-18-4

immunoglobulin G1- kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)], monoclonal antibody with cleavable prodomain;
gamma1 heavy chain (1-446) [VH (Homo sapiens IGHV3- 7*01 (77.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [9.7.9] (26-34.52-58.97-105)) (1-116) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, D12, L14 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230- 339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (117-446)], (219-256')-disulfide with kappa light chain (1'- 256') [cleavable prodomain (1'-41') fused to V-KAPPA (Homo sapiens IGKV1-13*02 (85.3%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (68-74.92-94.131-139)) (42'-149') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (195), V101 (233) (150'-256')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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