Надравалеуцел

Rec. INN (наименование, зарегистрированное ВОЗ)

allogeneic natural killer (NK) cells isolated from peripheral blood leukapheresis of individual donors., The cells are co-cultured in media containing interleukin 15 (IL-15) and nicotinamide (NAM, niacinamide) with expansion enhanced by the presence of feeder cells. The final cell population consists of 97-99% CD3-CD56+ NK cells, with >10% expressing CD16 (also known as FcγRIII) and CD62L (also known as L-selectin) and with capacity to degranulate (surface expression of CD107α [Lysosome-associated membrane glycoprotein 1]; >10%), and to kill target cells (>10%) in co-culture assays against human cancer cell lines.

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