Нафимэстроцел

Rec. INN (наименование, зарегистрированное ВОЗ)

allogeneic multilineage differentiating stress-enduring (Muse) cells derived from bone marrow of healthy human donors. The cells are expanded by adherent culture under hypoxic conditions to enrich for stage-specific embryonic antigen-3 (SSEA-3) positive cells. The substance contains Muse cells (≥ 50%) that are double positive for CD105 and the embryonic stem cell marker SSEA-3 and mesenchymal stromal cells (CD105+; <50%). Cells are negative for monocyte marker CD14, B cell marker CD19, hematopoietic stem cell marker CD34, leukocyte marker CD45, and human leukocyte antigen (HLA) DR. Cells have pluripotency, secrete fibroblast growth factor (FGF), hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF), and produce antifibrotic/fibrolytic factors (matrix metalloproteinases).

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