Навенибарт

Prop. INN (наименование, предложенное ВОЗ)

2803430-16-0

immunoglobulin G1-kappa, anti-[Homo sapiens KLKB1 (kallikrein B 1, plasma prekallikrein (zymogen), kininogenin, Fletcher factor, KLK3) proteolytically cleaved by F12 (factor FXII), active plasma kallikrein (EC 3.4.21.34)], humanized monoclonal antibody;
H-gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV1-69*08 (81.4%) -(IGHD) -IGHJ4*01 (92.9%) L123>T (116), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v21 CH2 Y15.1, T16, E18 (CH1 R120 (218) (122-219), hinge 1-15 (220-234), CH2 M15.1>Y (256), S16>T (258), T18>E (260) (235-344), CH3 E12 (360), M14 (362) (345-449), CHS K2>del (450)) (122-450)], (224-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-16*01 (82.1%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')]; dimer (230-230'':233-233'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line, derived from CHO-K1 cell line, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

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