Навепегритид

Rec. INN (наименование, зарегистрированное ВОЗ)

2413551-27-4

C-type natriuretic peptide (CNP), human, (89-126)-fragment (1-38) (CNP-38), conjugated at N⁶ of Lys26 with four O-methylpoly(ethylene glycol) chains (approx. 10 kDa each) via a cleavable tetraantennary linker;
L-leucyl-L-glutaminyl-L-α-glutamyl-L-histidyl-L-prolyl-L-asparaginyl-L-alanyl-L-arginyl-L-lysyl-L-tyrosyl-L-lysylglycyl-L-alanyl-L-asparaginyl-L-lysyl-L-lysylglycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-N⁶-{N²-[N²,N⁶-bis(6-{[(3RS)-1-{3-[(3-{(2RS)-2,3-bis[α-methylpoly(oxyethylene)-ω-oxy]propoxy}propyl)amino]-3-oxopropyl}-2,5-dioxopyrrolidin-3-yl]sulfanyl}hexanoyl)-L-lysyl]-N²-methyl-N¹-[2-(methylamino)ethyl]-L-isoasparaginyl}-L-lysyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L- cysteine (22-38)-disulfide

C₂₃₁H₃₈₆N₆₄O₆₇S₅ (C₂H₄O)_4n с n ≈ 220-245

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