Небратамиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2694723-68-5

immunoglobulin scFv-G1-scFv-scFv_L-kappa, anti-[Homo sapiens TNFRSF9 (TNF receptor superfamily member 9, 4-1BB, ILA, CD137)], anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)], anti-[Homo sapiens ROR1 (receptor tyrosine kinase like orphan receptor 1)] and anti-[Homo sapiens CD3D (CD3 delta) and CD3E (CD3 epsilon, Leu-4) dimer], humanized monoclonal antibody, tetraspecific, octavalent;
scFv-G1-scFv-scFv fused heavy chain humanized (1-1227) [scFv kappa-heavy anti-TNFRSF9 humanized (1-246) [V-KAPPA (Homo sapiens IGKV1-12*01 (83.1%) -IGKJ4*01 (100%), CDR-IMGT [6.3.13] (27-32.50-52.89-111)) (1-111) -20-mer tetrakis(tetraglycyl-seryl) linker (112-131) -VH (Homo sapiens IGHV3-64*04 (82.1%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.7.10] (156-163.181-187.226-235)) (132-246)] -10-mer bis(tetraglycyl-seryl) linker (247-256) -gamma-1 heavy chain anti-CD274 humanized (257-700) [VH (Homo sapiens IGHV3-23*03 (77.7%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.7.10] (281-288.306-312.351-360)) (257-371) -Homo sapiens IGHG1*01v, G1m17,1>G1m3,1, CH1 R120, CH3 D12, L14, G1v14-1 CH2 A1.3, A1.2, A1, G1v20 CH2 A105 (CH1 K120>R (468) (372-469), hinge 1-15 (470-484), CH2 L1.3>A (488), L1.2>A (489), G1>A (491), K105>A (576) (485-594), CH3 D12 (610), L14 (612) (595-699), CHS K2>del (700)) (372-700)] -10-mer bis(tetraglycyl-seryl) linker (701-710) -scFv heavy-kappa anti-ROR1 humanized (711-965) [VH (Homo sapiens IGHV3-23*03 (81.6%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.15] (736-743.761-768.807-821)) (711-832) -20-mer tetrakis(tetraglycyl-seryl) linker (833-852) -V-KAPPA (Homo sapiens IGKV1-27*01 (88.9%) -(IGHD) -IGKJ4*01 (83.3%), CDR-IMGT [8.3.13] (879-886.904-906.943-955)) (853-965)] -10-mer bis(tetraglycyl-seryl) linker (966-975) -scFv heavy-kappa anti-CD3D-CD3E dimer humanized (976-1227) [VH (Homo sapiens IGHV3-66*01 (86.6%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.7.14] (1001-1008.1026-1032.1071-1084)) (976-1095) -20-mer tetrakis(tetraglycyl-seryl) linker (1096-1115) -V-KAPPA (Homo sapiens IGKV1-5*01 (90.1%) -IGKJ4*01 (90.9%), CDR-IMGT [6.3.14] (1142-1047.1165-1167.1204-1217)) (1116-1227) ]]; (474-217')-disulfide with kappa light chain anti-CD274 humanized (1'-217') [V-KAPPA (Homo sapiens IGKV1-12*01 (89.7%) -IGKJ4*01 (100%), CDR-IMGT [6.3.12] (27-32.50-52.89-100)) (1'-110') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (156), V101 (194) (111'-217')]; dimer (480-480'':483-483'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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