Нелдалеуцел

Prop. INN (наименование, предложенное ВОЗ)

autologous multiple-tumour-associated antigen specific T lymphocytes prepared from peripheral blood mononuclear cells (PBMCs), collected by apheresis. The T lymphocytes are purified by depleting CD56+ cells from the PBMCs, and then pulsed with peptides that are derived from six tumor- associated antigens: preferentially expressed antigen in melanoma (PRAME), Wilms tumor 1 (WT1), New York esophageal 1 (NY-ESO-1), synovial sarcoma X breakpoint 2 (SSX2), melanoma-associated antigen A4 (MAGE-A4) and survivin. The cells are expanded in medium containing recombinant cytokines interleukin 6 (IL-6), 7 (IL-7), 12 (IL-12), and 15 (IL- 15). The final cells consist of a mixture of CD4+ and CD8+ T lymphocytes, that include effector memory (CD45RA-CD197-; on average 45%), central memory (CD45RA-CD197+; on average 29%), naïve (CD45RA+CD197+; on average 21%) and terminally-differentiated effector memory (CD45RA+CD197-; on average 5%) T lymphocytes. The cells demonstrate antigen specificity by interferon gamma (IFN-γ) enzyme-linked immunosorbent spot (ELISpot) analysis for all six tumour-associated antigens

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