Незастомиг

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

472420038

2657613-60-8

immunoglobulin G4-kappa, anti-[Homo sapiens FOLH1 (folate hydrolase, prostate specific membrane antigen, PSMA)] and anti-[Homo sapiens CD28 (T cell specific surface glycoprotein CD28, TP44)], Homo sapiens monoclonal antibody, bispecific, bivalent;
gamma4 heavy chain anti-FOLH1 Homo sapiens (1-450) [VH (Homo sapiens IGHV3-30*03 (90.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG4*01, G4v5 h P10, nG4m(a) CH2 L92, G4v7 CH2 delE1.4, P1.3, V1.2, A1.1 (CH1 (125-222), hinge 1-12 S10>P (232) (223-234), CH2 E1.4>del, F1.3>P (237), L1.2>V (238), G1.1>A (239), L92 (312) (235-343), CH3 (344-448), CHS (449-450)) (125-450)], (138-215')-disulfide with kappa light chain Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV3-20*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27'-33'.51'-53'.90'-98')) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154'), V101 (192') (109'-215')];
gamma4 heavy chain anti-CD28 Homo sapiens (1''-448'') [VH (Homo sapiens IGHV4-59*01 (96.9%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.7.16] (26''-33''.51''-57''.96''-111'')) (1''-122'') -Homo sapiens IGHG4*01, G4v5 h P10, nG4m(a) CH2 L92, G4v7 CH2 delE1.4, P1.3, V1.2, A1.1, G4v8 CH3 R115, F116, P125 (CH1 (123''-220''), hinge 1-12 S10>P (230'') (221''-232''), CH2 E1.4>del, F1.3>P (235''), L1.2>V (236''), G1.1>A (237''), L92 (310'') (233''-341''), CH3 H115>R (436''), Y116>F (437''), L125>P (446'') (342''-446''), CHS (447’’-448'')) (123''-448'')], (136''-215''')-disulfide with kappa light chain Homo sapiens (1'''-215''') [V-KAPPA (Homo sapiens IGKV3-20*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27'''-33'''.51'''-53'''.90'''-98''')) (1'''-108''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154'''), V101 (192''') (109'''-215''')]; dimer (230-228'':233-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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