Ниватротамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB16654

2278244-14-5

immunoglobulin G1-kappa anti-[Homo sapiens GD2 (ganglioside GD2)], each kappa chain being fused to a scFv anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], monoclonal antibody, bispecific;
gamma1 heavy chain anti-GD2 (1-449) [VH (Mus musculus IGHV2-9*02 (79.2%) -(IGHD) -IGHJ3*01 (91.7%) A128>S (119)/Homo sapiens IGHV3-33*01 (72.2%) -(IGHD) -IGHJ4*01 (92.3%)) CDR-IMGT [8.7.13] (26-33.51-57.96-108) (1-119) -Homo sapiens IGHG1*08p (100%), G1m3,1, G1v29 CH2 A84.4, G1v20 CH2 A105 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 N84.4>A (299), K105>A (324) (233-342), CH3 D12 (358), L14 (360) (343-447), CHS (448-449)) (120-449)],
(222-211')-disulfide with kappa light chain anti-GD2 fused to scFv anti-CD3E (1'-484') [kappa light chain anti-GD2 (1'-211') [V-KAPPA anti-GD2 (Mus musculus IGKV6-32*02 (84.9%) -(IGHD) -IGKJ2*03 (90.0%) S120>Q (97)/Homo sapiens IGKV3-15*01 (78.9%) -IGKJ2*03 (100%)) CDR-IMGT [6.3.6] (27-32.50-52.89-94) (1'-104') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (150), V101 (188) (105'-211')]-17-mer threonyl-seryl-tris(tetraglycyl-seryl linker (212'-228') -scFv heavy-kappa anti-CD3E (229'-484') [VH anti-CD3E G49>C (272), C114>S (333) (Homo sapiens IGHV3-30*10 (70.4%) -(IGHD) -IGHJ4*01 (85.7%) L123>P (342)) CDR-IMGT [8.8.12] (254-261.279-286.325-336) (229'-347') -30-mer hexakis(tetraglycyl-seryl) linker (348'-377') -V-KAPPA anti-CD3E (Homo sapiens IGKV1-33*01 (81.1%) -IGKJ2*02 (80.0%) Q120>C (476), E125>Q (481)) CDR-IMGT [5.3.9] (404-408.426-428.465-473) (378'-484')]]; dimer (228-228":231-231")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, non-glycosylated

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