Нофазинлимаб
NofazinlimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2377845-98-0
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], humanized monoclonal antibody;
gamma4 heavy chain humanized (1-442) [VH (Homo sapiens IGHV1-69*08 (83.5%) -(IGHD) -IGHJ4*01 (93.3%) L123>M (110), CDR-IMGT [8.8.8] (26-33.51-58.97-104)) (1-115)-Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (116-213), hinge 1-12 S10>P (223) (214- 225), CH2 (226-335), CH3 (336-440), CHS (441-442)) (116-442)], (129-219')-disulfide with kappa light chain humanized (1'-219') [V-KAPPA (Homo sapiens IGKV2- 30*02 (91.0%) -IGKJ2*01 (100%), CDR-IMGT [11.3.9] (27-37.55-57.94-102)) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158), V101 (196) (113'- 219')]; dimer (221-221'':224-224'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-K1, glycoform alfa
gamma4 heavy chain humanized (1-442) [VH (Homo sapiens IGHV1-69*08 (83.5%) -(IGHD) -IGHJ4*01 (93.3%) L123>M (110), CDR-IMGT [8.8.8] (26-33.51-58.97-104)) (1-115)-Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (116-213), hinge 1-12 S10>P (223) (214- 225), CH2 (226-335), CH3 (336-440), CHS (441-442)) (116-442)], (129-219')-disulfide with kappa light chain humanized (1'-219') [V-KAPPA (Homo sapiens IGKV2- 30*02 (91.0%) -IGKJ2*01 (100%), CDR-IMGT [11.3.9] (27-37.55-57.94-102)) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158), V101 (196) (113'- 219')]; dimer (221-221'':224-224'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-K1, glycoform alfa
Структура
Иностранные названия
- Nofazinlimabum (латинское)
- Nofazinlimab (английское)
- Nofazinlimab (немецкое)
- Nofazinlimab (французское)
- Nofazinlimab (испанское)
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