Оберотатуг равтанзин

Rec. INN (наименование, зарегистрированное ВОЗ)

2641919-35-7

immunoglobulin G1-kappa, anti-[Homo sapiens LY75 (human lymphocyte antigen 75, C-type lectin domain family 13 member B, CLEC13B, DEC-205, CD205)], Homo sapiens monoclonal antibody; conjugated to ravtansine;
H-gamma1 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV3-15*01 (98.0%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.10.10] (26-33.51-60.99-108)) (1-119) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-214')-disulfide with L-kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (88.4%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1SV, glycoform alfa; conjugated at N⁶ of an average of 3.5 lysyl residues with 4-[(5-{[(2S)-1-{[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^10,14.0^3,5]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy}-1-oxopropan-2-yl](methyl)amino}-2-methyl-5-oxopentan-2-yl)disulfanyl]butanoyl (ravtansine) groups

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