Обриндатамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

2069959-72-2

immunoglobulin G1 scFv-h-CH2-CH3(_scFv)_h-CH2-CH3, anti-[Homo sapiens CD276 (B7H3, B7-H3, B7RP-2)] and anti-[Homo sapiens CD3E (CD3 epsilon)], monoclonal antibody, bispecific;
IG scFv-h-CH2-CH3 single chain, anti-CD276 and anti-CD3E (1-504) [scFv-V-kappa-VH anti-CD276 and anti-CD3E (1-240) [V-KAPPA anti-CD276 (Homo sapiens IGKV1D-13*01 (85.1%) -IGHJ2*02 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1-107) -8-mer triglycyl-seryl-tetraglycyl linker (108-115) –VH anti-CD3E (Mus musculus IGHV10-1*02 (89.9%) -(IGHD) -GHJ3*01 (93.3%)/Homo sapiens IGHV3-72*01 (87.0%) -(IGHD) -IGHJ6*01 (90.9%)) CDR-IMGT [8.10.16] (141-148.166-175.214-229) (116-240)] -linker-E-coil (241-277) [6-mer diglycyl-cysteinyl-triglycyl linker (241-246) -28-mer tetrakis(glutamyl-valyl-dialanyl-leucyl-glutamyl-lysyl) E-coil motif (247-274) -3-mer triglycyl linker (275-277)] –Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1, G1v14 CH2 A1.3, A1.2, G1v32 CH3 W22 (knob) (278-504) [hinge 6-15 (278-287), CH2 L1.3>A (291), L1.2>A (292) (288-397), CH3 E12 (413), M14 (415), T22>W (423) (398-502), CHS (503-504)]]; (243-243')-disulfide with the IG scFv single chain, anti-CD3E and anti-CD276 (1'-274') [scFv V-lambda-VH anti-CD3E and anti-CD276 (1'-240') [V-LAMBDA anti-CD3 (Mus musculus IGLV1*01 (81.2%) -IGLJ1*01 (100%)/Homo sapiens IGLV7-46*01 (77.9%) -IGLJ3*02 (100%)) CDR-IMGT [9.3.9] (26-34.52-54.91-99) (1'-109') -9-mer tetraglycyl-seryl-tetraglycyl linker (110'-118') -VH anti-CD276 (Homo sapiens IGHV3-48*02 (91.8%) -(IGHD) -IGHJ4*01 (85.7%)) CDR-IMGT [8.8.15] (144-151.169-176.215-229) (119'-240')] -6-mer diglycyl-cysteinyl-triglycyl linker (241'-246') -28-mer tetrakis(lysyl-valyl-dialanyl-leucyl-lysyl-glutamyl) K-coil motif (247'-274')];
(283-6'':286-9'')-bisdisulfide with the IG h-CH2-CH3 chain, IGHG1*03 nG1m1, G1v14 CH2 A1.3, A1.2, IGHG1v33 CH3 S22, A24, V86 (hole) (1''-227'') [hinge 6-15 (1''-10''), CH2 L1.3>A (14), L1.2>A (15) (11''-120''), CH3 E12 (136), M14 (138), T22>S (146), L24>A (148), Y86>V (187), H115>R (215) (121''-225''), CHS (226''-227'')]; produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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