Олинтатуг тезирин

Prop. INN (наименование, предложенное ВОЗ)

2851870-30-7

immunoglobulin G1-kappa, anti-[Homo sapiens KAAG1 (kidney associated DCDC2 antisense RNA 1, kidney associated antigen 1, RU2AS, RU2 antisense gene protein)], humanized and chimeric monoclonal antibody, conjugated on an average of 2-3 cysteinyl residues to tesirine;
H-gamma1 heavy chain humanized (1-445) [VH (Homo sapiens IGHV1-46*01 (80.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 D12 (355), L14 (357) (340-444), CHS K2>del (445)) (117-445)], (219-219')-disulfide with L-kappa light chain chimeric (1'-219') [V-KAPPA Musmus/Homsap (Mus musculus IGKV1-117*01 (89.0%) -IGKJ2*03 (90.9%) S120>Q (105)/Homo sapiens IGKV2-29*02 (89.0%) -IGKJ2*01 (100%), CDR-IMGT [11.3.9] (27'-37'.55'-57'.94'-102')) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158'), V101 (196') (113'-219')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa; substituted at the sulfur atoms of 2-3 l-cysteinyl residues on an average among 219, 225, 228, 219', 219'', 225'', 228'' and 219''' with radical group (1^11aS,9¹¹S,9^11aS,16S,19S,52³RS)-9¹¹-hydroxy-1⁷,9⁷-dimethoxy-1²,9²,16-trimethyl-1⁵,9⁵,10,15,18,21,49,52²,52⁵-nonaoxo-19-(propan-2-yl)-1⁵,1^11a,9¹¹,9^11a-tetrahydro-1¹H,9¹H,9⁵H-2,8,11,24,27,30,33,36,39,42,45-undecaoxa-14,17,20,48-tetraaza-1(8),9(8,10)-bis(pyrrolo[2,1-c][1,4]benzodiazepina)-52(1)-pyrrolidina-13(1,4)benzenadopentacontaphan-52³-yl (tesirine)

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