Омпекимиг

Prop. INN (наименование, предложенное ВОЗ)

USAN (наименование, принятое к употреблению в США)

2981477-39-6

immunoglobulin (L-kappa-H-gamma1(_L-VH-G1(CH1-h))_L-kappa)_(H-gamma1_L-kappa), anti-[Homo sapiens IL4 (interleukin 4, IL-4)], anti-[Homo sapiens IL13 (interleukin 13, IL-13)] and anti-[Homo sapiens IL33 (interleukin 33, IL-33)], monoclonal antibody, trispecific, trivalent;
fused L-kappa-H-gamma1 chain anti-IL13 and anti-IL4 (1-674) [L-kappa anti-IL13 (1-218) [V-KAPPA (Homo sapiens IGKV1-39*01 (82.8%) -IGKJ4*01 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1-111) -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (157), V101 (195)) (112-218)] -5-mer (tetraglycyl-seryl) linker (219-223) -H-gamma1 heavy chain anti-IL4 (224-674) [VH (Homo sapiens IGHV2-5*08 (87.0%) -(IGHD) -IGHJ3*01 (92.9%) M123>T (339), CDR-IMGT [10.7.13] (249-258.276-282.321-333)) (224-344) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14, 6-G1v14-1 CH2 A1.3, A1.2, A1, 9-G1v24 CH3 L107, S114, 14-G1v99-1 hinge E6, CH3 E24 (CH1 R120>K (441) (345-442), hinge 1-15 D6>E (448) (443-457), CH2 L1.3>A (461), L1.2>A (462), G1>A (464) (458-567), CH3 E12 (583), M14 (585), L24>E (595), M107>L (655), N114>S (661) (568-672), CHS (673-674)) (345-674)]]; (218-221')-disulfide with L-VH-G1(CH1-h) light chain anti-IL13 (1'-221') [VH (Homo sapiens IGHV3-21*07 (91.8%) -IGHD -IGHJ1*01 (100%), CDR-IMGT [8.7.12] (26'-33'.51'-57'.96'-107')) (1'-118') -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120 (CH1 R120>K (215') (119'-216'), hinge 1-5 (217'-221')) (119'-221')]; (447-218''')-disulfide with L-kappa light chain anti-IL4 (1'''-218''') [V-KAPPA (Homo sapiens IGKV1-39*01 (87.9%) -IGKJ4*01 (100%), CDR-IMGT [10.3.9] (27'''-36'''.54'''-56'''.93'''-101''')) (1'''-111''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (157'''), V101 (195''')) (112'''-218''')];
H-gamma1 heavy chain anti-IL33 (1''-451'') [VH (Homo sapiens IGHV3-7*01 (89.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.14] (26''-33''.51''-58''.97''-110'')) (1''-121'') -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, 6-G1v14-1 CH2 A1.3, A1.2, A1, 9-G1v24 CH3 L107, S114, 14-G1v99-2 hinge R6, CH3 R88 (CH1 R120>K (218'') (122''-219''), hinge 1-15 D6>R (225'') (220''-234''), CH2 L1.3>A (238''), L1.2>A (239''), G1>A (241'') (235''- 344''), CH3 E12 (360''), M14 (362''), K88>R (413''), M107>L (432''), N114>S (438'') (345''-449''), CHS (450''-451'')) (122''-451'')], (224''-213'''')-disulfide with L-kappa light chain anti-IL33 (1''''-213'''') [V-KAPPA (Homo sapiens IGKV1-6*01 (88.8%) -IGKJ4*01 (90.9%), CDR-IMGT [6.3.8] (27''''-32''''.50''''-52''''.89''''-96'''')) (1''''-106'''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (152''''), V101 (190'''')) (107''''- 213'''')]; dimer (453-230":456-233")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

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