Ополимоген капмилисбак

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

Recombinant live-attenuated double-deleted (LADD) strain of Listeria monocytogenes (Lm ∆actA/∆inlB) expressing three recombinant fusion proteins as follows:
(i) the N-terminal 100 amino acids of the Lm ActA (actin-assembly inducing protein precursor) protein (ActAN100), 5 tandem copies of a 21 amino acid fragment of human epidermal growth factor receptor variant III (EGFRvIII) and human protein SSX2 (synovial sarcoma, X breakpoint 2, also known as cancer/testis antigen 5.2 (CT5.2), tumor antigen HOM-MEL-40), under the control of the Lm actA promoter, and contained within an expression cassette of 1434 bp inserted at the actA locus;
(ii) the N-terminal 100 amino acids of the Lm ActA protein (ActAN100), 5 tandem copies of a 21 amino acid fragment of human epidermal growth factor receptor variant III (EGFRvIII) and amino acids 33-386 of human prostatic acid phosphatase (PAP), under the control the Lm actA promoter, and contained within an expression cassette of 2057 bp inserted at the inlB (internalin B) locus; (iii) the N-terminal 100 amino acids of the Lm ActA protein (ActAN100), 5 tandem copies of a 21 amino acid fragment of human epidermal growth factor receptor variant III (EGFRvIII) and amino acids 11-234 of human homeobox protein Nkx-3.1 (NKX3-1) plus amino acids 1-20, 44-138 and 169-750 of human glutamate carboxypeptidase 2 (also known as folate hydrolase 1 (FOLH1), prostate-specific membrane antigen (PSMA)), under the control the Lm actA promoter, and contained within an expression cassette of 4984 bp at the tRNA^Arg locus.

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