Опортузумаб монатокс

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB05319

945228-48-8

immunoglobulin scFv fusion protein, anti-[Homo sapiens tumorassociated calcium signal transducer 1 (TACSTD1, gastrointestinal tumor-associated protein 2, GA733-2, epithelial glycoprotein 2, EGP2, epithelial cell adhesion molecule Ep-CAM, KSA, KS1/4 antigen, M4S1, tumor antigen 17-1A, CD326)] humanized monoclonal antibody scFv fused with Pseudomonas aeruginosa exotoxin A;
hexahistidyl -humanized scFv [V-KAPPA (Homo sapiens IGKV1- 39*01 (78%)- IGKJ1*01, I126>L) [11.3.9] (7-118) -26-mer linker -VH (Homo sapiens IGHV7-4-1*02 -(IGHD)-IGHJ4*01, V124>L) [8.8.9] (145-260)] -20-mer linker -Pseudomonas aeruginosa exotoxin A (ETA) [277-633 precursor fragment, containing domain II (281-393) with furin proteolytic cleavage site (302-313), domain Ib (394-433), domain III (434-637)] (281-637) -hexahistidyl-lysyl-aspartyl-glutamylleucyl

C₃₀₇₂H₄₇₂₃N₈₇₇O₉₅₂S₁₂

695580,48 г/моль

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