Опуготамиг

Prop. INN (наименование, предложенное ВОЗ)

2779564-38-2

immunoglobulin (G1_L-kappa)_scFvkh-G1(h-CH2-CH3), anti-[Homo sapiens FOLR1 (folate receptor 1, folate receptor alpha, FR-alpha, adult folate-binding protein, FBP, ovarian tumor-associated antigen MOv18)], biparatopic, bivalent;
H-gamma1 heavy chain, anti-FOLR1 (1-447) [VH (Mus musculus IGHV1-37*01 (87.8%) -(IGHD) -IGHJ4*01 (93.3%) S123>T (113), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v33 CH3 S22, A24, V86 (hole) (CH1 R120>K (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 E12 (357), M14 (359), T22>S (367), L24>A (369), Y86>V (408) (342-446), CHS K2>del (447)) (119-447)], (221-218’)-disulfide with L-kappa light chain, anti-FOLR1 (1’-218’) [V-KAPPA (Mus musculus IGKV3-9*01 (80.8%) -IGKJ2*01 (100%), CDR-IMGT [10.3.9] (27’-36’.54’-56’.93’-101’)) (1’-111’) -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157’), V101 (195') (112’-218’)];
scFvkh-G1(h-CH2-CH3) heavy chain, anti-FOLR1 (1''-479'') [V-KAPPA (Mus musculus IGKV5-43*01 (86.3%) -IGKJ2*03 (91.7%) S120>C (101''), CDR-IMGT [6.3.10] (27''-32''.50''-52''.89''-98'')) (1''-108'')-20-mer tetrakis(tetraglycyl-seryl) linker (109''-128'') -VH (Mus musculus IGHV5-17*02 (88.8%) -(IGHD) -IGHJ3*01 (91.7%) A128>S (246''), CDR-IMGT [8.8.11] (154''-161''.179''-186''.225''-235'')) (129''-246'') -2-mer (glycyl-seryl) linker (247''-248'') -Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 CH3 E12, M14, G1v37 h S5, G1v32 CH3 W22 (knob) (hinge 1-15 C5>S (253'') (249''-263''), CH2 (264''-373''), CH3 T22>W (399'') (374''-478''), CHS K2>del (479'')) (249''-479'')]; dimer (227-259'': 230-262'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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