Осираместроцел

Prop. INN (наименование, предложенное ВОЗ)

allogeneic mesenchymal stromal cells (MSC) derived from umbilical cord blood and culture-expanded from a working cell bank (WCB)., The initial cells are separated from the cord blood and cultured in complete media with fetal bovine serum to create the master cell bank and then working cell bank from which the cells are further sub-cultured in media containing fibroblast growth factor (FGF), insulin-like growth factor-1 (IGF-1), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), hydrocortisone and a lengthened analogue of insulin-like growth factor 1 (IGF-1 Long R3). The MSC cells can differentiate into osteoblasts, chondrocytes, and adipocytes, and have the capability to differentiate into various other cell types. The MSCs express multipotent stromal cell markers CD44, CD73 and CD105 (≥90%), and low levels (≤10%) of CD11b, CD34, CD45, CD19 and HLA-DR and secrete transforming growth factor beta-1 (TGF-β1) (≥1400 pg/ml)

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