Озекибарт

Rec. INN (наименование, зарегистрированное ВОЗ)

DB18675

2539847-03-3

only-heavy-chain immunoglobulin G1, anti-[Homo sapiens TNFRSF10B (TNF receptor superfamily member 10B, death receptor 5, DR5, TNF-related apoptosis-inducing ligand TRAIL receptor 2, TRAILR2, TRAIL-R2, TR-2, CD262)], humanized monoclonal antibody, monospecific, tetravalent, agonist;
gamma1 heavy chain humanized (1-480) [VH humanized (Homo sapiens IGHV3-23*01 (82.5%) -(IGHD) -IGHJ4*01 (91.7%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -6-mer bis(bisglycyl-seryl linker (124-129) -[VH humanized (Homo sapiens IGHV3-23*01 (82.5%) -(IGHD) -IGHJ4*01 (91.7%), CDR-IMGT [8.8.16] (155-162.180-187.226-241)) (80-252) -4-mer tetraglycyl linker (253-256) -Homo sapiens IGHG1*01, h-CH2-CH3, G1m1 CH3 D12, L14, G1v65 CH2 del(E1.4, L1.3, L1.2) (hinge 6-15 (257-266), CH2 (E1.4, L1.3, L1.2)>del 268^269 (267-373), CH3 D12 (389), L14 (391) (374-478), CHS (479-480)) (257-480)]; dimer (262-262'':265-265'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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