Озурепрубарт

Prop. INN (наименование, предложенное ВОЗ)

2823332-50-7

immunoglobulin G1-kappa, anti-[Homo sapiens IGHE (immunoglobulin constant epsilon) region of IgE heavy chain, Fc region of IgE)], humanized monoclonal antibody;
H-gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV3-66*01 (84.7%) -(IGHD) -IGHJ3*01 (85.7%) M123>L (116), CDR-IMGT [9.7.14] (26-34.52-58.97-110)) (1-121) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v21 CH2 Y15.1, T16, E18 (CH1 R120>K (218) (122-219), hinge 1-15 (220-234), CH2 M15.1>Y (256), S16>T (258), T18>E (260) (235-344), CH3 E12 (360), M14 (362) (345-449), CHS (450-451)) (122-451)], (224-218')-disulfide with L-kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV1-39*01 (87.9%) -IGKJ2*01 (100%), CDR-IMGT [10.3.9] (27'-36'.54'-56'.93'-101')) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157'), V101 (195') (112'-218')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa

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