Озурифтамаб ведотин
Ozuriftamab vedotinМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
USAN (наименование, принятое к употреблению в США)
PubChem
445594976
CAS
2460400-11-5
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens ROR2 (receptor tyrosine kinase-like orphan receptor 2, NTRKR2)], monoclonal antibody, conjugated to auristatin E;
gamma1 heavy chain (1-451) [VH (Homo sapiens IGHV5-10-1*04 (79.4%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*01 (100%), G1m17,1 (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 D12 (361), L14 (363) (346-450), CHS K2>del (451)) (123-451)], (225-213')-disulfide with kappa light chain (1'-213') [V-KAPPA Musmus/Homsap (Mus musculus IGKV4-57*01 (75.3%) -IGKJ4*01 (83.3%) S120>Q (99), L124>V (103)/Homo sapiens IGKV1-13*02 (70.5%) -IGKJ1*01 (91.7%), CDR-IMGT [5.3.9] (27-31.49-51.88-96)) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152), V101 (190) (107'-213')]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa, conjugated, on an average of 4 cysteinyl, to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker
gamma1 heavy chain (1-451) [VH (Homo sapiens IGHV5-10-1*04 (79.4%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*01 (100%), G1m17,1 (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 D12 (361), L14 (363) (346-450), CHS K2>del (451)) (123-451)], (225-213')-disulfide with kappa light chain (1'-213') [V-KAPPA Musmus/Homsap (Mus musculus IGKV4-57*01 (75.3%) -IGKJ4*01 (83.3%) S120>Q (99), L124>V (103)/Homo sapiens IGKV1-13*02 (70.5%) -IGKJ1*01 (91.7%), CDR-IMGT [5.3.9] (27-31.49-51.88-96)) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152), V101 (190) (107'-213')]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa, conjugated, on an average of 4 cysteinyl, to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker
Структура
Иностранные названия
- Ozuriftamabum vedotinum (латинское)
- Ozuriftamab vedotin (английское)
- Ozuriftamab vedotin (немецкое)
- Ozuriftamab védotine (французское)
- Ozuriftamab vedotina (испанское)
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