Паканалотамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

immunoglobulin scFv-scFv, anti-[Homo sapiens TNFRSF17 (TNF receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, B cell maturation antigen, BCMA, BCM, TNFRSF13A, CD269)] and anti-[Homo sapiens CD3E (CD3 epsilon)], monoclonal antibody single chain, bispecific;
IG scFv-scFv single chain, anti-TNFRSF17 and anti-CD3E (1-504) [scFv-VH-V-kappa anti-TNFRSF17 (1-243) [VH (Homo sapiens IGHV1-46*01 (85.7%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.14] (26-33.51-58.97-110) (1-121) -15-mer tris(tetraglycyl-seryl) linker (122-136) -V-KAPPA (Homo sapiens IGKV1-33*01 (91.6%) - IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (163-168.186-188.225-233) (137-243)] -6-mer seryl-tetraglycyl-seryl linker (244-249) -scFv-VH-V-lambda anti-CD3E (250-498) [VH (Mus musculus IGHV10-1*02 (91.9%) -(IGHD) -IGHJ3*01 (86.7%)/Homo sapiens IGHV3-73*01 (87%) -(IGHD) -IGHJ5*01 (100%)) CDR-IMGT [8.10.16] (275-282.300-309.348-363) (250-374) -15-mer tris(tetraglycyl-seryl) linker (375-389) -V-LAMBDA (Homo sapiens IGLV7-43*01 (85.1%) -IGLJ3*02 (100%) CDR-IMGT [9.3.9] (415-423.441-443.480-488) (390-498)] -hexahistidine (499-504)], produced in Chinese hamster ovary (CHO) cells, non-glycosylated

Поделиться этой страницей