Палсуцибеп пегол

Rec. INN (наименование, зарегистрированное ВОЗ)

2218524-43-5

engineered human lipocalin-2 binding protein (LCN2, neutrophil gelatinase-associated lipocalin, NGAL, siderocalin, oncogene 24p3) variant (N-terminal M added, Q>H²⁸, A>E⁴⁰, I>V⁴¹, Q>M⁴⁹, Y>W⁵², K>E⁵⁹, S>I⁶⁸, L>M⁷⁰, F>P⁷¹, R>L⁷², K>A⁷³, K>E⁷⁴, D>E⁷⁷, W>L⁷⁹, I>F⁸⁰, R>Q⁸¹, N>G⁹⁶, Y>G¹⁰⁰, L>R¹⁰³, Y>G¹⁰⁶, K>V¹²⁵, S>¹²⁷W, Y>V¹³², K>W¹³⁴, I>V¹³⁵), anti-[human hepcidin (human liver-expressed antimicrobial peptide 1, LEAP-1, HAMP, putative liver tumor regressor, PLTR)], non-glycosylated, produced by Escherichia coli, conjugated at the S atom of C87 with PEG (~30 kDa);
artificial recombinant protein, derived from human lipocalin-2 (LCN2, neutrophil gelatinase-associated lipocalin, NGAL, siderocalin, oncogene 24p3), designed for binding to hepcidin (human liver-expressed antimicrobial peptide 1, LEAP-1, HAMP, putative liver tumor regressor, PLTR) by exchanging 25 residues; L-methionyl-[Q²⁸H, A⁴⁰E, I⁴¹V, Q⁴⁹M, Y⁵²W, K⁵⁹E, S⁶⁸I, L⁷⁰M, F⁷¹P, R⁷²L, K⁷³A, K⁷⁴E, D⁷⁷E, W⁷⁹L, I⁸⁰F, R⁸¹Q, N⁹⁶G, Y¹⁰⁰G, L¹⁰³R, Y¹⁰⁶G, K¹²⁵V, S¹²⁷W, Y¹³²V, K¹³⁴W, I¹³⁵V]-lipocalin-2, non-glycosylated, produced by Escherichia coli, conjugated at the S atom of Cys87 with a (3RS)-1-(3-{3-[α-methylpoly(oxyethylene)-ω-amino]propyl}- 3-oxopropyl)-2,5-dioxopyrrolidin-3-yl group (~30 kDa)

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