Палверафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2850355-87-0

human vascular endothelial growth factor receptor 1 (VEGFR-1) fragment, anti-(human vascular endothelial growth factor (VEGF), fused via a (G₄S)₃ peptide linker to the N-terminus of both heavy chains of a humanized immunoglobulin G1-kappa anti-(human programmed cell death 1 ligand 1 [PD-L1, programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, B7-H1, CD274]), glycoform alfa;
human vascular endothelial growth factor receptor 1 (VEGFR-1) fragment 129-228 comprising the second extracellular domain of the VEGF receptor (VEGFR-D2), [N¹⁹⁶>A⁶⁸]-variant, anti-(human vascular endothelial growth factor (VEGF) (1-100 in the current sequence) fused, via a (G₄S)₃ peptide linker (101-115), to gamma 1 heavy chain (116-563) [VH (Homo sapiens IGHV3-23*04 -(IGHD) - IGHJ4*01, CDR-Kabat [5.17.9] (146-150.165-181.214-222)) (116- 233) -Homo sapiens IGHG1*03 (CH1 (234-331), hinge (332-346), CH2 S⁴¹⁴>A, E⁴⁴⁹>A, K⁴⁵⁰>A (347-456), CH3 (457-561), CHS (562-563)) (234-563)], (336-214')-disulfide with kappa light chain (1'- 214') [V-KAPPA (Homo sapiens IGKV1-12*01 -IGKJ1*01, CDR- Kabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; dimer (342-342'', 345-345'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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