Памлектабарт тисманитин
Pamlectabart tismanitinМНН
Prop. INN (наименование, предложенное ВОЗ)
CAS
2925692-67-5
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens TNFRSF17 (tumor necrosis factor (TNF) receptor superfamily member 17, B cell maturation antigen, BCMA, TNFRSF13A, CD269)], humanized monoclonal antibody, conjugated at cysteine residues 268 and 268'' with tismanitin, comprising a cleavable linker and a synthetic a-amanitin derivative;
H-gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-74*01 (84.5%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v76 CH2 C27 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 D27>C (268) (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV3-15*01 (90.5%) -IGKJ2*01 (81.8%) Q120>A (100'), I126>L (106') , CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa; substituted at the sulfur atoms of cysteine residues 268 and 268'' with group 1-(3-{[(2S)-3-methyl-1-oxo-1-{[(2S)-1-oxo-1-{4-[({1,8-anhydro:C2.4,S3.8-cyclo[l-α-aspartyl-(4R)-4-hydroxy-l-prolyl-(4R)-4,5-dihydroxy-l-isoleucyl-l-tryptophylglycyl-l-isoleucylglycyl-l-cystein]-C4.1-yl}amino)methyl]anilino}propan-2-yl]amino}butan-2-yl]amino}-3-oxopropyl)-2,5-dioxopyrrolidin-3-yl (tismanitin)
H-gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-74*01 (84.5%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v76 CH2 C27 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 D27>C (268) (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV3-15*01 (90.5%) -IGKJ2*01 (81.8%) Q120>A (100'), I126>L (106') , CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa; substituted at the sulfur atoms of cysteine residues 268 and 268'' with group 1-(3-{[(2S)-3-methyl-1-oxo-1-{[(2S)-1-oxo-1-{4-[({1,8-anhydro:C2.4,S3.8-cyclo[l-α-aspartyl-(4R)-4-hydroxy-l-prolyl-(4R)-4,5-dihydroxy-l-isoleucyl-l-tryptophylglycyl-l-isoleucylglycyl-l-cystein]-C4.1-yl}amino)methyl]anilino}propan-2-yl]amino}butan-2-yl]amino}-3-oxopropyl)-2,5-dioxopyrrolidin-3-yl (tismanitin)
Структура
Иностранные названия
- Pamlectabartum tismanitinum (латинское)
- Pamlectabart tismanitin (английское)
- Pamlectabart tismanitin (немецкое)
- Pamlectabart tismanitine (французское)
- Pamlectabart tismanitina (испанское)
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