Памватамиг

Rec. INN (наименование, зарегистрированное ВОЗ)

485663853

2750004-05-6

immunoglobulin G1-kappa, anti-[Homo sapiens MET (met proto-oncogene, hepatocyte growth factor (HGF) receptor, HGFR, scatter factor (SF) receptor, HGF/SF receptor, receptor tyrosine-protein kinase c-met, papillary renal cell carcinoma 2, RCCP2)] and anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)], Homo sapiens monoclonal antibody, bispecific;
gamma1 heavy chain anti-MET Homo sapiens (1-452) [VH (Homo sapiens IGHV7-4-1*02 (95.9%) -(IGHD) -IGHJ5*02 (100%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, E12, M14, G1v72 CH3 D7, E24 (CH1 R120 (220) (124-221), hinge 1-15 (222-236), CH2 (237-346), CH3 E12 (362), M14 (364), L7>D (357), L24>E (374) (347-451), CHS K2>del (452)) (124-452)], (226-214')-disulfide with common kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')];
gamma1 heavy chain anti-EGFR Homo sapiens (1''-451'') [VH (Homo sapiens IGHV1-18*01 (98.0%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.15] (26''-33''.51''-58''.97''-111'')) (1''-122'') -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, E12, M14, G1v73 CH3 K7, K22 (CH1 R120 (219'') (123''-220''), hinge 1-15 (221''-235''), CH2 (236''-345''), CH3 E12 (361''), M14 (363''), L7>K (356''), T22>K (371'') (346''-450''), CHS K2>del (451'')) (124''-452'')], (226''-214''')-disulfide with common kappa light chain Homo sapiens (1'''-214''') [V-KAPPA (Homo sapiens IGKV1-39*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'''-32'''.50'''-52'''.89'''-97''')) (1'''-107''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'''), V101 (191''') (108'''-214''')]; dimer (232-231'':235-234'')-bisdisulfide, produced in a Chinese hamster ovary (CHO) cell line, co-expressing the RMD enzyme (GDP-6-deoxy-D-lyxo-4-hexulose reductase), glycoform alfa

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