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Prop. INN (наименование, предложенное ВОЗ)

2921676-04-0

immunoglobulin (H-gamma1_L-kappa)_scFvkh-G1(h-CH2-CH3), anti-[Homo sapiens KLK2 (kallikrein-2, kallikrein related peptidase 2, kallikrein 2 prostatic) and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], Homo sapiens and humanized monoclonal antibody, bispecific, bivalent;
H-gamma1 heavy chain Homo sapiens, anti-KLK2 (1-455) [VH (Homo sapiens IGHV4-59*01 (100%) -(IGHD) -IGHJ6*01 (94.4%), CDR-IMGT [8.7.19] (26-33.51-57.96-114)) (1-125) -Homo sapiens IGHG1*03v G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v14-67 CH2 A1.3, A1.2, S27, G1v68 CH3 V6, L22, L79, W81 (CH1 R120>K (222) (126-223), hinge 1-15 (224-238), CH2 L1.3>A (242), L1.2>A (243), D27>S (273) (239-348), CH3 T6>V (358), E12 (364), M14 (366), T22>L (374), K79>L (400), T81>W (402) (349-453), CHS (454-455)) (126-455)], (228-214')-disulfide with L-kappa light chain Homo sapiens, anti-KLK2 (1'-214') [V-KAPPA (Homo sapiens IGKV1-9*01 (97.9%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')];
scFvkh-G1(h-CH2-CH3) heavy chain humanized, anti-CD3E (1''-475'') [V-KAPPA (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27''-32''.50''-52''.89''-97'')) (1''-107'') -20-mer (GGSEGKSSGSGSESKSTGGS) linker (108''-127'') -VH (Homo sapiens IGHV3-21*01 (89.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.9] (153''-160''.178''-185''.224''-232'')) (128''-243'') -Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 CH3 E12, M14, G1v14-67 CH2 A1.3, A1.2, S27, G1v37 h S5, G1v69 CH3 V6, Y7, A85.1, V86 (hinge 1-15 C5>S (248'') (244''-258''), CH2 L1.3>A (262''), L1.2>A (263''), D27>S (293'') (259''-368''), CH3 T6>V (378''), L7>Y (379''), E12 (384''), M14 (386''), F85.1>A (433''), Y86>V (435'') (369''-473''), CHS (474''-475'')) (244''-475'')]; dimer (234-254'': 237-257'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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